Myotonic dystrophy research: imaging result files ( DTI, VBM) from a 5-year longitudinal follow-up study
- Gliem, Carla1
-
Minnerop, Martina2
- Roeske, Sandra3
- Gärtner, Hanna4
- Schoene-Bake, Jan-Christoph5
- Adler, Sandra1
- Witt, Juri-Alexander6
- Hoffstaedter, Felix7
- Schneider-Gold, Christiane8
- Betz, Regina C.9
- Helmstaedter, Christoph6
- Tittgemeyer, Marc10
- Amunts, Katrin11
- Klockgether, Thomas12
- Weber, Bernd13
- Kornblum, Cornelia14
- 1. Department of Neurology, University Hospital Bonn, Bonn, Germany
- 2. Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany and Center for Movement Disorders and Neuromodulation, Department of Neurology and Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany
- 3. Department of Neurology, University Hospital Bonn, Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
- 4. Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany
- 5. Life and Brain Center, Department of NeuroCognition-Imaging, Bonn, and Department of Epileptology, University Hospital Bonn, Bonn, Germany and Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
- 6. Department of Epileptology, University Hospital Bonn, Bonn, Germany
- 7. Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany and Institute of Clinical Neuroscience and Medical Psychology/ Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany
- 8. Department of Neurology, Ruhr-University Bochum, St. Josef Hospital, Bochum, Germany
- 9. Institute of Human Genetics, University Bonn, Bonn, Germany
- 10. Max-Planck-Institute for Neurological Research, Cologne, Germany
- 11. Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany and C. and O. Vogt Institute for Brain Research, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- 12. Department of Neurology, University Hospital Bonn, Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany and Center for Rare Diseases Bonn (ZSEB), University Hospital Bonn, Bonn, Germany
- 13. Life and Brain Center, Department of NeuroCognition-Imaging, Bonn, and Department of Epileptology, University Hospital Bonn, Bonn, Germany and Center for Economics and Neuroscience, University Bonn, Bonn, Germany
- 14. Department of Neurology, University Hospital Bonn, Bonn, Germany and Center for Rare Diseases Bonn (ZSEB), University Hospital Bonn, Bonn, Germany
Description
This ZIP-file contains supplementary data belonging to the manuscript
"Tracking the brain in myotonic dystrophy: a 5-year longitudinal follow-up study", published in PLOS ONE.
In this manuscript we aimed to examine the natural history of brain involvement in adult-onset myotonic dystrophies type 1 and 2 (DM1, DM2). We conducted a longitudinal observational study to examine functional and structural cerebral changes in myotonic dystrophies. We enrolled 16 adult-onset DM1 patients, 16 DM2 patients, and 17 controls. At baseline (T1) and at follow-up (T2) participants underwent neurological, neuropsychological, and 3T-brain MRI examinations using identical study protocols that included voxel-based morphometry and diffusion tensor imaging.
The ZIP-file contains imaging result files from the different statistical analyses.