FORMULATION, OPTIMIZATION AND EVALUATION OF RASAGILINE MESYLATE IN SITU NASAL GEL

The aim of the present study is to formulate and evaluate nasal insitu gel of Rasagiline Mesylate. Nasal gels were prepared using combination of polymers like carbopol 934, HPMC K4M and sodium alginate and evaluated in terms of clarity, viscosity, gelation, ex vivo drug permeation studies. Ex vivo drug permeation profiles showed that formulation containing sodium alginate provided a better controlled release of the drug than the other formulations. Formulation F3 showed better drug release of about 87.62% and it exhibited better in situ gelling properties, pH, clarity and viscosity. Mucoadhesive insitu nasal gel of Rasagiline mesylate delivers the drug directly to brain and provides controlled release of the drug.