EVALUATION OF LEPIDIUM SATIVUM SEED MUCILAGE AS A BINDER IN TABLET FORMULATION

The aim of the current study was to extract the mucilage from Garden Cress (Lepidium Sativum Linn) seeds and to investigate the compressional behavior of mucilage in tablet formulation in comparison with standard binder such as starch using Heckel and Kawakita plot. Using paracetamol as model drug granules was prepared with different concentration (1%, 2%, and 3%) of the mucilage and starch by wet granulation method. The granules and tablets were evaluated for their flow properties, hardness, weight variation, thickness etc., and found to have hardness and disintegration time slightly more compared to starch as binder and hence satisfactory to prepare compressed tablets. The study revealed that the Lepidium sativum mucilage compared favourably with the standard starch as binder but plasticity of starch is more than Lepidium sativum mucilage as binder.