Journal article Open Access

ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTI-PARKINSON'S SCREENING OF AZOMETHINE ANALOGUES THROUGH HSP90 INHIBITION

Dr. M. Ganga Raju*, Divya N

Heat-shock protein (Hsp90) a group of molecular chaperones responsible for managing protein folding and quality control in cell environment. Hsp90 requires a series of co-chaperones to assemble into a super-chaperone complex for its function. The current study is piloted to perform antibacterial, antifungal, anti-inflammatory, anti-Parkinson’s and antioxidant activities of Hsp90 inhibitors. The compounds S30 and S47 were synthesized and the maximum tolerable dose was found to be 2000 mg/kg, animals were administered with a dose of 100 mg/kg bd. wt and 200 mg/kg bd. wt. From the results dose dependent reduction in symptoms like muscular rigidity, ptosis, tremor, bradykinesia, gait alteration, righting reflex, swim test and locomotor behavior were observed. The histopathological studies of drug treated also showed the restoration. The two test drugs S30 and S47 possess antibacterial, antifungal, anti-inflammatory, anti-Parkinson’s and antioxidant activities. Further study is needed to confirm the exact mechanism of action of the test drugs S30 and S47.

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