STUDY OF GROWTH PROMOTION AND HEALTH BENEFITS OF AYU-809 GENERAL NUTRITIONAL SUPPLEMENT IN RATS

The growth promotion and health benefits of AYU-809 –a general nutritional supplement was investigated using carbon tetrachloride (CCl4 in olive oil 0.5ml/kg bw ip) intoxicated Sprague Dawley rats. The AYU-809 in milk was administered orally at a dose of 4.80 g/kg bw po for 28 days. The CCl4 was administered to all the groups except group I (normal control) once in three days. Silymarin (100 mg/kg po) was used as a standard hepatoprotective drug. Body weight, feed efficiency and body circumference were measured every 5th day during the study. On 29th day, animals were anaesthetized and blood was collected by retro orbital. Hemoglobin content and RBC count, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase (ALP) were determined. Liver homogenate was prepared and lipid peroxidation (LPO) and Superoxide Dismutase (SOD) levels were measured and histopathology of liver tissue also examined. Our findings suggest that AYU-809, a general nutritional supplement formulated by Nutraceuticals division M/s Ayurwin Pharma Pvt Ltd, Bengaluru, possesses growth promoting, hepato protecting and antioxidant properties. The data provide useful insight into the possibility of using AYU-809 to promote the growth in children associated with growth related disorders.