A biplot correlation range for group-wise metabolite selection in mass spectrometry
- 1. Korea University
- 2. University of Colorado
- 3. Georgia Institute of Technology
- 4. Emory University
- 5. Hanyang University
Description
Background
Analytic methods are available to acquire extensive metabolic information in a cost-effective manner for personalized medicine, yet disease risk and diagnosis mostly rely upon individual biomarkers based on statistical principles of false discovery rate and correlation. Due to functional redundancies and multiple layers of regulation in complex biologic systems, individual biomarkers, while useful, are inherently limited in disease characterization. Data reduction and discriminant analysis tools such as principal component analysis (PCA), partial least squares (PLS), or orthogonal PLS (O-PLS) provide approaches to separate the metabolic phenotypes, but do not offer a statistical basis for selection of group-wise metabolites as contributors to metabolic phenotypes.
Methods
We present a multivariate statistical approach termed ‘biplot correlation range (BCR)’ to provide the group-wise selection of metabolic markers contributing to metabolic phenotypes.
Results
Using a simulated multiple-layer system that often arises in complex biologic systems, we show the feasibility and superiority of the proposed approach in comparison of existing approaches based on false discovery rate and correlation. To demonstrate the proposed method in a real-life dataset, we used LC-MS based metabolomics to determine spectrum of metabolites present in liver mitochondria from wild-type (WT) mice and thioredoxin-2 transgenic (TG) mice. We select discriminatory variables in terms of increased score in the direction of class identity using BCR. The results show that BCR provides means to identify metabolites contributing to class separation in a manner that can complement a statistical method by false discovery rate in complex data analysis for predictive health and personalized medicine.
Files
LICENSE.txt
Files
(2.2 MB)
Name | Size | Download all |
---|---|---|
md5:b0d44ab78713af7f38aeaff29203dc9f
|
1.8 MB | Download |
md5:5ce5457eb17d89558601786fd40e3742
|
5.9 kB | Download |
md5:a9fba6cb870e440f70d88c6a4849cb63
|
55.3 kB | Download |
md5:c493535d638d203ae0ca1f65ac1a4314
|
1.3 kB | Download |
md5:093e9f5e52364ec6c1e1d96679523b1e
|
151 Bytes | Download |
md5:e8a64a0ab185d1801bef2a37abb198d1
|
1.2 kB | Download |
md5:fb5772e5a8ce2bd2a23e4b29fbca0406
|
475 Bytes | Download |
md5:d791ab80b5da63976876df17548f89de
|
877 Bytes | Download |
md5:0ee890384bc52e6aae01eb84e27aacf0
|
1.4 kB | Download |
md5:47a7d8b1e1235ae38648ba065f69ba47
|
1.1 kB | Download |
md5:d75ca3fbdfe46bfd85ef792247dc15dc
|
1.4 kB | Download |
md5:e3f487330f3f30bae3fdd1f919ae5d8c
|
1.5 kB | Download |
md5:a199e03200f8abce82d481ff40e3b936
|
1.4 kB | Download |
md5:862a8899508e251ff33d19adbfd663e9
|
3.4 kB | Download |
md5:603663312d6dcb3df0f237ecf3099d1a
|
2.9 kB | Download |
md5:23c1ae3d04cfaae20286cdb8562f6f74
|
122 Bytes | Download |
md5:5385163b4baa15d56e2c0a5498768cdf
|
26.5 kB | Download |
md5:7e0f041a50e9f8a419ac57db95e1aaba
|
2.1 kB | Download |
md5:e7b1079e5c83a064b5ba7201b36f77ad
|
39.0 kB | Download |
md5:93ac969ade81e65cdbadba33a059e069
|
63.8 kB | Download |
md5:630443d5a3b7969103f9333dd5782f9b
|
15.4 kB | Download |
md5:596d856138cbe2f6dbdd24bb7144590a
|
1.4 kB | Download |
md5:b135608ec718a18674a8df9c84e6a1a3
|
1.1 kB | Download |
md5:aa07e51303aa875be0d4a2b5951e529a
|
802 Bytes | Download |
md5:223bbbf7fd6e77eb32cdcd661b884a0d
|
2.1 kB | Download |
md5:b4c6cde30fce4cbf90ef6faff630c689
|
979 Bytes | Download |
md5:925b0198d6f3ab35dc7143e62d3f3dd6
|
554 Bytes | Download |
md5:eb789b3043a92472d538f61413b8f899
|
2.0 kB | Download |
md5:36e0673b632a956475fe0351a9fc2494
|
176 Bytes | Download |
md5:424ea8907f40397e7b4fbd4faa64162e
|
980 Bytes | Download |
md5:9c4242ab53e6a4bd35da99aad363673f
|
3.4 kB | Download |
md5:7106cb052236170ba8e51666f1c68e3d
|
1.3 kB | Download |
md5:55cb4ea8661780c3c5f9df3939d6c165
|
6.6 kB | Download |
md5:a46d34a3e5f99ad0e37fb47995021251
|
577 Bytes | Download |
md5:f74d96b8a37dca1e4738b02e5bb582bf
|
758 Bytes | Download |
md5:c029fee1cf38bc2100e59b195589d468
|
622 Bytes | Download |
md5:8c53bfa8d3aa3f089179cdd535022585
|
878 Bytes | Download |
md5:30ce1a9ca3bb8667fb04b16004f347b8
|
307 Bytes | Download |
md5:de92699bcfb7ade9d9af160b09210867
|
973 Bytes | Download |
md5:0a5159a7b3e2ad915dae34780ed68f70
|
422 Bytes | Download |
md5:9bfdd32db4ae19ff978802e464b2ba51
|
36.3 kB | Download |
md5:e22b7facfc893ef7e195d7910ccfb42f
|
36.0 kB | Preview Download |
md5:f010761976494907f22f918b38edb9ce
|
87 Bytes | Download |
md5:04b423f11406c1b71f1a4cf558f59d09
|
280 Bytes | Download |
md5:75ac31ebcfa6884adca922585ab6a798
|
3.7 kB | Download |
md5:e9b72a8c2f6d4d6bbe57a2981c0f84ee
|
4.6 kB | Preview Download |
md5:0815ef984b31600d4661003e8cb2d0c9
|
1.2 kB | Download |
md5:81fc12c4664db4b7cee112c9670f729e
|
1.5 kB | Download |
md5:40bd72e24348ce46db3711e30d554551
|
246 Bytes | Download |
md5:f2ae7b01c34cb97c7474b3bc3c047c19
|
20.1 kB | Download |
md5:264f6b57ba94b732b6dd3b88fc046028
|
20.3 kB | Download |
md5:e0befbfe9eefb33599102dc97eaa98e1
|
20.0 kB | Download |
md5:0ef19e5520654e8409b639797408d204
|
19.9 kB | Download |
md5:a32edb84299aa2dd9ec3e27ce7c9b229
|
287 Bytes | Preview Download |
md5:87965b1e21935c4d4ca28604834f4337
|
308 Bytes | Preview Download |