Journal article Open Access

EXTENDED RELEASE TABLET FORMULATION OF A MACROLIDE ANTIBIOTIC

Packiaraj Jeyachandran Manohari, Venkateswaran Chidambaram Seshadri and Janakiraman Kunchithapatham

Clarithromycin is a macrolide antibiotic. The objective is to design the extended release tablet of Clarithromycin which will exhibit comparative in-vitro and in-vivo drug release profile as that of marketed product. The designed formulation utilizes a combination of Hydroxypropyl Methylcellulose 5 cps and 15 cps as rate controlling polymers for drug release. The process is a wet granulation process using FBP. The finalized extended release tablet showed comparative in vitro and in vivo drug release profile against the marketed product BIAXIN XL FILM TAB®. Also the physico-chemical properties of the finalized extended release tablets of Clarithromycin was found to be stable for 3 months at of 40°C / 75% RH.

Files (907.3 kB)
Name Size
26.pdf
md5:6966bb0ac434dd0c918ef87ac61e8991
907.3 kB Download
10
26
views
downloads
All versions This version
Views 1010
Downloads 2626
Data volume 23.6 MB23.6 MB
Unique views 1010
Unique downloads 2424

Share

Cite as