March 31, 2017 Journal article Open Access

A STUDY ON PROTECTIVE ROLE OF PRUNUS AMYGDALUS ON ALCOHOL INDUCED RETROGRADE AMNESIA

Komati. Anusha*1, Preethi Chavan1, Jyothi Vadthya1, G. Bhavana1, Jabbarlal Naik2 Korra, Suresh Naik2

Ethanol and Prunus amygdalus (PA) are most widely used in the world. PA is a popular nourishing food, along with its nutritional values it also possess medicinal values like anti-stress, anti oxidant, immunostimulant, lipid lowering and laxative. Ethanol- induced retrograde amnesia was investigated using Morries Water Maze, Elevated plus Maze. Anxiety and locomotion was assessed using open field test. Rats received Prunus amygdalus suspension (150mg/kg, 300mg/kg, and 600mg/kg., oral) for 7 days, and Alcohol (3g/kg, 20%, i.p) in 6th day of the treatment. The next day they were accessible for Behavioral assessment. Rats receiving Alcohol shows significant reduction in escape latency (MWM), Time spent in open arm (EPM), Number of ambulations and rearing (OFT) and increase in Immobility time (FST). The current study evidenced learning and memory impairment, anxiety, and depression symptoms in rats characterized by behavioral impairment, increased oxidative stress, apoptosis, following exposure to ethanol. PA suspension helps in recovery of disrupted memory after ethanol inducing alterations in brain, ultimately, improved the memory (spatial and learning), anxiety and depression.