Journal article Open Access
N. N. Kadam*, R. R. Patil, S. S. Gaikwad, M. P. Wagh
Solid Lipid Nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependence properties, lipid nanoparticles offer possibility to develop new therapeutics. SLNs introduced at the beginning of the 1990s represents an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro and nanoparticles as they have advantages like controlled drug release and targeted drug delivery with increased stability. SLN are administrated by various route such as oral, parenteral, rectal, respiratory, nasal, topical and ocular have been proposed for the delivery of SLNs. The present review paper highlight on various advantages, disadvantages, various production methods, drug incorporation model, factor affecting loading capacity of drug in lipid, Analytical techniques for characterization of SLNs like photon correlation spectroscopy, electron microscopy, atomic force microscopy, dynamic light scattering [DLS], differential scanning calorimetry [DSC], static light scattering, acoustic method and nuclear magnetic resonance [NMR] are discussed along with application of SLNs.