Journal article Open Access

ISOLATION AND STRUCTURAL ELUCIDATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES COMPOUNDS FROM CANTHIAM COROMENDELICUM

Arulprakash. P, Sasidharan. P, Jayachitra. A

The present study deals with the identifying a Squalene from medicinal plants for pharmaceutical application. Squalene was isolated from Canthiam coromendelicum using soxhlet apparatus. Methanol is a good solvent for extraction of the Squalene. The crude extractions of C. coromendelicum shows many Secondary metabolites present in the extracts such as Squalene, phytol, n-Butyl are major compounds to find out from the plant profile using GC-MS, UV-Vis, FT-IR, HPTLC, NMR and Mass. Then it was used for further pharmaceutical applications such as antioxidant, antibacterial and cytotoxicity assay. The Squalene possess enhanced characteristic of antioxidant activity against for their free radicals (DPPH, NO, SO, H2O2), antibacterial activity against Salmonella typi, E. Coli, Pseudomonas putida, Staphylococcus aureus. It shows good cytotoxicity activity against Hep-2 cells. The characterization analysis proved that the isolated Squalene would be a good and potential drug for cancer. In future it will be useful in many biomedical applications.

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