Evaluation of Heteropogon contortus (L.) Beauv. Methanolic extract for Mast cell, Cell Membrane and free radical stabilization

Methanolic extract of Heteropogon contortus (L.) Beauv was screened for mast cell stabilization (in vitro anti-histaminic) and membrane stabilization (in vitro anti-inflammatory) effects. Extracts was also evaluated for antioxidant effect (DPPH, % RRI of DPPH, reducing power and metal chelation). In addition extract was standardized using chromatographic fingerprinting and spectroscopic quantitation for phytoconstituents contents. HC-ME exhibited good anti-hisatminic effect in by reducing histamine release quantity from C-48/80 induced mast cells destabilization. Stabilizes hypotonic and heat induced destabilized cell membrane. Findings of the above studies helps to reveals that, HC-ME not only exhibit antioxidant activity but also exhibit membrane and mast cell stabilization potential.