Dataset Open Access

Meta-analysis results of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Küpers, LK; et al.

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni<1.06x10-7).

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