AN EXPERIMENTAL CONTROL RESEARCH TO ASCERTAIN THE BOTTOM EFFECTS OF HOMOCYSTEINE ON THE MEASUREMENT OF BONE MASS

Objectives: To ascertain whether homocysteine is unblameable or the actual participant in affecting bone. The study aimed at getting to the bottom of the effect of homocysteine on bone mass measurement.

Methodology: This study of experimental-control category organized between December 2016 to November 2017 at Allied Hospital, Faisalabad includes 30 standard patients having a normal bone mass measurement with an equal number of subjects having at least one yardstick for measuring the density of osteoporosis in femur neck or coccyx vertebrae. Subjects of the two categories compared on the basis of sex and age. Bone mass measurement calculated by DXA and fasting antidote homocysteine quantity calculated by EIA kits in all qualified subjects.

Results: Average individual values of antidote measure of homocysteine were 11.970 03.09 and 11.670±04.38 ὶmol/l in control and experimental categories. The difference (p=0.7610) of the values of the two categories was not that big. There was no significant connection in the experimental and control categories of antidote homocysteine measure and bone mass measurement. The values were as: coccyx vertebrae in control category (r=0.0250, p=0.90), coccyx vertebrae in experimental category (r=0.0710, p=0.7160), femur cervix in control category (r=0.2760, p=0.1470), femur cervix in experimental category (r=0.0010, p=0.9980).

Conclusion: In spite of a lot of research about the consequence of homocysteine on the escalated possibility of fractures caused by osteoporosis, our study did not reveal the link between antidote measure of homocysteine and bone mass measurement. Due to the massive number of elements influencing the density of bone, ending deductions need immense considerations with attention paid to other astonishing factors.

Keywords: Bone Mass Measurement, Femur Neck, Coccyx Vertebrae, Homocysteine and Osteoporosis