Published March 13, 2026 | Version v1
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Figure 1 from: Ivanov H, Linev A, Pochileev I, Stoyanova V (2026) Droplet digital PCR outperforms qPCR by revealing clinically relevant low-frequency KRAS mutations in colorectal cancer. Pharmacia 73: 1-7. https://doi.org/10.3897/pharmacia.73.e187140

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  • 1. Department of Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria

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Figure 1 Confusion matrix comparing qPCR and ddPCR results for KRAS mutation detection in 50 FFPECRC samples. ddPCR detected all qPCR-positive cases and identified six additional low-VAF mutations not detected by qPCR. This demonstrates that ddPCR achieves perfect sensitivity relative to qPCR while identifying additional mutation-positive cases, underscoring its improved ability to capture low-frequency variants.

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Journal article: 10.3897/pharmacia.73.e187140 (DOI)
Journal article: https://zenodo.org/record/19029281 (URL)