Published June 20, 1972 | Version v1

Reductive and oxidative cleavage of 5-phenyl-oxazline-3-carboxylic acid

  • 1. Imperial College London
  • 2. Imperial College London

Description

The reductive cleavage of 5-phenyl-isoxazoline-3-carboxylic acid with zinc in acetic anhydride to give 4-phenyl-2-acetamido-butyrolactone is described. Oxidative fragmentation of t-butyl-5-phenyl-isoxazoline-3-peroxycarboxyalate parallels the mass spectral fragmentation to give benzaldehyde and 3-hydroxy-3-phenylproprionitrile.

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