Dexmedetomidine Effects On Shivering and Core Temperature in Awake Normal Subjects

Ten normal adult human subjects received a rapid intravenous infusion of two liters of cold (4ºC) isotonic saline on two separate test days, and we measured their core body temperature, shivering, hemodynamics and sedation for two hours.  On one test day, fluid infusion was preceded by placebo infusion.  On the other test day, fluid infusion was preceded by 1.0 µg/kg bolus of dexmedetomidine over 10 minutes.