Хронобиологические особенности влияния экзогенного мелатонина на гормональную активность щитовидной железы у молодых крыс = Chronobiological features of the effect of exogenous melatonin on hormone thyroid activity in young rats
Authors/Creators
- 1. SI ”V. Danilevsky Institute of Endocrine Pathology Problems of the NAMS of Ukraine”
Description
CHRONOBIOLOGICAL FEATURES OF THE EFFECT OF EXOGENOUS MELATONIN ON HORMONE THYROID ACTIVITY IN YOUNG RATS
A. R. Gevorkyan
SI ”V. Danilevsky Institute of Endocrine Pathology Problems of the NAMS of Ukraine”, Kharkiv
Abstract
The effect of 10-day-long evening injection of melatonin in a physiological dose range on the functional state of the thyroid gland considering its activity at different times of the day was studied in young male Wistar rats population. It is shown that the course injection of melatonin to young rats of reproductive age with normal functioning of the pineal and thyroid causes the dose-dependent reduction of thyroid hormones in the blood of both day and night. The results of this study demonstrate the antithyroid effect of exogenous melatonin in the reproductive age and suggest that additional melatonin therapy, even at physiological doses in young reproductive age is contraindicated.
Key words: thyroid gland, thyroid hormones, melatonin, circadian rhythms