Express experimental evalution of mutagenic activity of complex phoshorus-containing organic mixtures = Експрес-експериментальна оцінка мутагенної активності складних фосфоровмісних органічних сумішей = Экспресс-экспериментальная оценка мутагенной активности сложных фосфоросодержащих органических смесей

Bagmut I. Yu., Zharova N. V., Popova T. M., Zhukov V. I., Stetsenko S. O. Express experimental evalution of mutagenic activity of complex phoshorus-containing organic mixtures = Експрес-експериментальна оцінка мутагенної активності складних фосфоровмісних органічних сумішей =Экспресс-экспериментальная оценка мутагенной активности сложных фосфоросодержащих органических смесей Journal of Education, Health and Sport. 2016;6(10):443-454. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.164190

http://ojs.ukw.edu.pl/index.php/johs/article/view/3971

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 02.09.2016. Revised 24.09.2016. Accepted: 30.10.2016.

UDK 579.695

EXPRESS EXPERIMENTAL EVALUATION OF MUTAGENIC ACTIVITY
OF COMPLEX PHOSPHORUS-CONTAINING ORGANIC MIXTURES

I. Yu. Bagmut, N. V. Zharova, T. M. Popova, V. I. Zhukov, *S. O. Stetsenko

Kharkiv Medical Academy of Postgraduate Education;
*Kharkiv National Medical University

Summary

Researching the mutagenic activity of organic phosphorus-containing mixtures of Esherichia Coli bacteria strain trp A 223 and the continuous cells culture of murine myeloma X63 also detected the presence of weak mutagenic properties in this group of xenobiotics. The concentrations of all compounds 400 and 1000 mg/l have bacteriostatic effect, and their lower concentrations in the range from 10 to 80 mg/l stimulate the mutagenic activity. Phosphorus-containing organic compounds can inhibit the synthesis of proteins, RNA and DNA in cell culture Vero depending on the concentration.

Key words: xenobiotics, carcinogenesis, mutagenesis, atherogenesis, suppression of immune deficiency, reproductive function, Esherichia Coli, cells culture of murine myeloma X63.