Published September 30, 2019
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Table 1 1 H in Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
Authors/Creators
- 1. ∗ & ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05, Hradec Králové, Czech & Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05, Hradec Králové, Czech Republic
Description
Table 1 1 H-NMR and 13 C-NMR data of new alkaloid 6 (diastereomeric ratio 1:1.1) isolated from Narcissus pseudonarcissus cv. Duch Master.
| POSITION | NARCIMATULINE | |||
|---|---|---|---|---|
| δC of | δH of isomer A | δC of | δH of isomer B | |
| isomer A | isomer B | |||
| 1 | 29.7 | 2.39–2.26 m | 29.6 | 2.39–2.26 m |
| 1.84–1.64 m | 1.84–1.64 m | |||
| 2 | 35.7 | 2.39–2.26 m | 35.6 | 2.39–2.26 m |
| 2.13–1.98 m | 2.13–1.98 m | |||
| 3 | 209.2 | 209.2 | ||
| 4 | 40.0 | 2.60 dd, overlapped | 40.0 | 2.56 dd, overlapped |
| (18.4, 2.9) | (18.0, 2.9) | |||
| 4a | 88.3 | 4.68 t (2.9) | 88.2 | 4.55 t (2.9) |
| 5a | 146.7 | 146.7 | ||
| 6 | 143.6 | 143.6 | ||
| 7 | 110.9 | 6.65 d, overlapped | 111.0 | 6.62 d, overlapped |
| (8.0) | (8.0) | |||
| 8 | 122.23 | 6.44 d (8.0) | 122.20 | 6.56 d (8.0) |
| 8a | 129.9 | 129.9 | ||
| 8b | 132.0 | 132.0 | ||
| 9 | 57.6 | 3.88 d, overlapped | 57.9 | 3.98 d (15.0) |
| (15.0) | 3.66 d (15.0) | |||
| 3.51 d (15.0) | ||||
| 11 | 52.3 | 3.05–2.88 m | 51.1 | 3.05–2.88 m |
| 2.86–2.74 m | ||||
| 12 | 37.4 | 2.13–1.98 m | 36.4 | 1.84–1.64 m |
| 1.56–1.50 m | 1.38–1.31 m | |||
| 13 | 47.5 | 47.4 | ||
| 1′ | 54.9 | 3.45 d (14.2) | 53.7 | 3.35 bs |
| 3.33–3.24 m | ||||
| 2′ | 122.8 | 122.8 | ||
| 3′ | 108.7 | 7.01 s | 108.4 | 7.07 s |
| 3a′ | 146.9 | 146.9 | ||
| 5′ | 101.0 | 6.00–5.98 m | 100.9 | 6.00–5.98 m |
| 6a′ | 146.0 | 145.8 | ||
| 7ֹ’ | 110.5 | 6.74 s | 110.3 | 6.77 s |
| 8′ | 133.6 | 133.4 | ||
| 9′ | 131.7 | 131.4 | ||
| 10′ | 130.4 | 6.83 d (7.4) | 130.2 | 6.71 d, overlapped |
| (7.4) | ||||
| 11′ | 117.9 | 6.68 t, overlapped | 117.9 | 6.62 t, overlapped |
| (7.4) | (7.4) | |||
| 12′ | 123.22 | 7.03 d, overlapped | 123.24 | 7.03 d, overlapped |
| (7.4) | (7.4) | |||
| 12a′ | 131.0 | 131.0 | ||
| 13′ | 28.6 | 3.05–2.88 m | 28.5 | 3.05–2.88 m |
| 2.86–2.74 m | 2.86–2.74 m | |||
| 14′ | 57.1 | 3.33–3.24 m | 56.9 | 3.33–3.24 m |
| 3.18 dd (17.5, 8.8) | 3.09 dd (18.4, 9.2) | |||
| 15a′ | 150.5 | 150.4 | ||
| N15′-CH3 | 38.8 | 2.25 s | 38.7 | 2.20 s |
| C6-OCH3 | 55.96 | 3.86–3.83 m | 55.95 | 3.86–3.83 m |
Spectra were acquired in chloroform-d at 500 MHz (1 H) and 125.7 MHz (13 C);
1 J values are in parentheses and reported in Hz; chemical shifts are given in ppm.
Notes
Published as part of Hulcová, Daniela, Maříková, Jana, Korábečný, Jan, Hošťálková, Anna, Jun, Daniel, Kuneš, Jiří, Chlebek, Jakub, Opletal, Lubomír, Simone, Angela De, Nováková, Lucie, Andrisano, Vincenza, Růžička, Aleš & Cahlíková, Lucie, 2019, Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease, pp. 4 in Phytochemistry 165 on page 4, DOI: 10.1016/j.phytochem.2019.112055, http://zenodo.org/record/10483285
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