Published March 20, 2025 | Version 1.0.1
Dataset Restricted

Data (A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans)

Authors/Creators

Description

To access the data, please complete the Data User Agreement by filling out the form provided in the link below. 

https://tinyurl.com/appliedcognition-dua

Once completed, kindly send it to research@appliedcognition.com along with your Zenodo ID for processing.

Notes

Hypnogram.csv

This file contains the hypnogram labels for every epoch and every sleep recording, labeled by a sleep neurologist as well as the labelling from the Applied Cognition investigational device. The sleep neurologist used all the polysomnography (PSG) channels for hypnogram labeling. The Applied Cognition device used its acquired EEG channel. 

  • ID: Unique id created from study identifier + participant identifier + sleep period

  • Channel: Label indicating label by the sleep neurologist reading the full PSG (“human”), algorithmic labeling using device or PSG single channels derivatives

  • Hypnogram: Hypnogram label

 

samples_morning.csv / samples_night.csv / samples_night_keep_waso.csv

These files contain device data at the block level. A block is approximately 300sec long of device recording that multiplexes EEG recordings with EIS recordings. Data in samples_night_keep_waso.csv file include the “wake after sleep onset” blocks.

  • Study: Study identifier (Benchmarking / Replication)

  • ID: Unique identifier created from study identifier + participant identifier + sleep period (morning/night)

  • Pid: Participant identifier

  • Visit: Visit number (visit 1 or visit 2)

  • Intervention: Random assignment to sleep/wake

  • Sleep: Set to true for sleep intervention

  • Block Number: Block number

  • Timestamp: Block start timestamp

  • Block hypnogram: Hypnogram label assigned to the block using EEG epochs. Hypnogram labels mapping: 0: Wake, 1: N1,  2: N2, 3: N3, 4: REM

  • dR: Change in resistance from previous block to current block

  • dDelta: Change in delta power from previous block to current block

  • dTheta: Change in theta power from previous block to current block

  • dAlpha: Change in alpha power from previous block to current block

  • dBeta: Change in beta power from previous block to current block

  • dGamma: Change in gamma power from previous block to current block

  • dHR: Change in heart rate from previous block to current block

  • dLFHFRatio: Change in the HRV ratio of LF and HF from previous block to current block

  • Dz_ref: Change in electrode impedance of sense electrode (right side) from previous block to current block

  • Dz_eeg: Change in electrode impedance of sense electrode (left side) from previous block to current block

  • Dz_bias_drvp: Change in electrode impedance of drive electrode (left side) from previous block to current block

  • Dz_drvn: Change in electrode impedance of reference electrode (right side) from previous block to current block

  • dHypno: Change in Hypnogram label from previous block to current block (eg. 2->3)

  • Resistance: Parenchymal resistance

  • Resistance_Norm_Factor: Parenchymal resistance starting normalization

  • Resistance_End_Avg: Parenchymal resistance ending value

 

Summary.csv

This file contains aggregated data for every participant’s visit. This file contains participant information, aggregated device data, MRI data, APOE4 status and screening assessments (MoCa & GDS)

 

Visit and Participant Columns

General visit information and participant details.

  • Study: Study identifier

  • Pid: Participant identifier

  • Visit: Visit number (v1 or v2)

  • Visit_type: Random assignment to sleep/wake

  • Age: Participant’s age

  • Gender: Participant’s gender

 

Device Columns

Data aggregated for each visit with one record per visit. For example, the change in parenchymal resistance for the overnight recording (in the interval between period 1 to period 2) is “Resistance_p1-p2”. Similarly, for the morning recording (interval between period 2 to period 3), the change in parenchymal resistance is “Resistance_p2-p3”.

  • Visit_p1-p2: Recording identifier of the overnight period (p1-p2)

  • Resistance_p1-p2: Overnight change in parenchymal resistance

  • Resistance_p2-p3: Morning change in parenchymal resistance

  • delta rel_p1-p2: Overnight average delta power normalized to values at start of overnight period

  • delta rel_p2-p3: Morning average delta power normalized to values at start of morning period

  • theta rel_p1-p2: Overnight average theta power normalized to values at start of overnight period

  • theta rel_p2-p3: Morning average theta power normalized to values at start of morning period

  • alpha rel_p1-p2: Overnight average alpha power normalized to values at start of overnight period

  • alpha rel_p2-p3: Morning average alpha power normalized to values at start of morning period

  • beta rel_p1-p2: Overnight average beta power normalized to values at start of overnight period

  • beta rel_p2-p3: Morning average beta power normalized to values at start of morning period

  • heart rate_p1-p2: Overnight average heart rate normalized to values at start of overnight period

  • heart rate_p2-p3: Morning average heart rate normalized to values at start of morning period

  • N1_p1-p2: Total time in minutes the participant was in N1 sleep overnight computed using the device EEG 

  • N2_p1-p2: Total time in minutes the participant was in N2 sleep overnight computed using the device EEG 

  • N3_p1-p2: Total time in minutes the participant was in N3 sleep overnight computed using the device EEG 

  • REM_p1-p2: Total time in minutes the participant was in REM sleep overnight computed using the device EEG 

  • WASO_p1-p2: Total time in minutes the participant was in WASO overnight computed using the device EEG 

  • N1_p2-p3: Total time in minutes the participant was in N1 sleep during the morning visit computed using the device EEG 

  • N2_p2-p3: Total time in minutes the participant was in N2 sleep during the morning visit computed using the device EEG 

  • N3_p2-p3: Total time in minutes the participant was in N3 sleep during the morning visit computed using the device EEG 

  • REM_p2-p3: Total time in minutes the participant was in REM sleep during the morning visit computed using the device EEG 

  • WASO_p2-p3: Total time in minutes the participant was in WASO during the morning visit computed using the device EEG

  • EEG Sample Time %_p1: Percentage of time that was spent doing EEG sampling. It is fixed per recording.

 

Polysomnography columns

The columns contain the total time in minutes the participant was in the N1, N2, N3, REM and WASO stages using polysomnography channel C4 either for overnight sleep (visit_type = Sleep) or morning sleep (visit_type = Awake)

  • C4 N1: Total time in minutes the participant was in N1 sleep

  • C4 N2: Total time in minutes the participant was in N2 sleep

  • C4 N3: Total time in minutes the participant was in N3 sleep

  • C4 REM: Total time in minutes the participant was in REM sleep

  • C4 WASO: Total time in minutes the participant was in WASO

 

Screening Assessment

  • MoCA: Montreal Cognitive Assessment

  • GDS: Geriatric Depression Scale

 

APOEe4

  • APOEe4: Boolean flag set to true in the presence of at least one copy of APOEe4

 

MRI Columns

  • CSF Max_Vel_p1: Absolute maximum velocity of CSF in Aqueduct of Sylvius at time point p1

  • CSF Max_Vel_p2:Absolute maximum velocity of CSF in Aqueduct of Sylvius at time point p2

  • CSF Max_Vel_p3: Absolute maximum velocity of CSF in Aqueduct of Sylvius at time point p3

  • Dstr Frontal _p1: Pseudodiffusion coefficient in frontal gray matter in mm2/s at time point p1

  • Dstr Frontal GM_p2: Pseudodiffusion coefficient in frontal gray matter in mm2/s at time point p2

  • Dstr Frontal GM_p3: Pseudodiffusion coefficient in frontal gray matter in mm2/s at time point p3

  • Dstr Frontal WM_p1: Pseudodiffusion coefficient in frontal white matter in mm2/s at time point p1

  • Dstr Frontal WM_p2: Pseudodiffusion coefficient in frontal white matter in mm2/s at time point p2

  • Dstr Frontal WM_p3: Pseudodiffusion coefficient in frontal white matter in mm2/s at time point p3

  • Dstr Parietal GM_p1: Pseudodiffusion coefficient in parietal gray matter in mm2/s at time point p1

  • Dstr Parietal GM_p2: Pseudodiffusion coefficient in parietal gray matter in mm2/s at time point p2

  • Dstr Parietal GM_p3: Pseudodiffusion coefficient in parietal gray matter in mm2/s at time point p3

  • Dstr Parietal WM_p1:Pseudodiffusion coefficient in parietal white matter in mm2/s at time point p1

  • Dstr Parietal WM_p2: Pseudodiffusion coefficient in parietal white matter in mm2/s at time point p2

  • Dstr Parietal WM_p3: Pseudodiffusion coefficient in parietal white matter in mm2/s at time point p3

  • Dstr Temporal GM_p1: Pseudodiffusion coefficient in temporal gray matter in mm2/s at time point p1

  • Dstr Temporal GM_p2: Pseudodiffusion coefficient in temporal gray matter in mm2/s at time point p2

  • Dstr Temporal GM_p3: Pseudodiffusion coefficient in temporal gray matter in mm2/s at time point p3

  • Dstr Temporal WM_p1: Pseudodiffusion coefficient in temporal white matter in mm2/s at time point p1

  • Dstr Temporal WM_p2: Pseudodiffusion coefficient in temporal white matter in mm2/s at time point p2

  • Dstr Temporal WM_p3: Pseudodiffusion coefficient in temporal white matter in mm2/s at time point p3

  • Dstr Occipital GM_p1: Pseudodiffusion coefficient in occipital gray matter in mm2/s at time point p1

  • Dstr Occipital GM_p2: Pseudodiffusion coefficient in occipital gray matter in mm2/s at time point p2

  • Dstr Occipital GM_p3: Pseudodiffusion coefficient in occipital gray matter in mm2/s at time point p2

  • Dstr Occipital WM_p1: Pseudodiffusion coefficient in occipital white matter in mm2/s at time point p1

  • Dstr Occipital WM_p2: Pseudodiffusion coefficient in occipital white matter in mm2/s at time point p2

  • Dstr Occipital WM_p3: Pseudodiffusion coefficient in occipital white matter in mm2/s at time point p3

  • Dstr SAS_p1: Pseudodiffusion coefficient in the subarachnoid CSF in mm2/s at time point p1

  • Dstr SAS_p2: Pseudodiffusion coefficient in the subarachnoid CSF in mm2/s at time point p2

  • Dstr SAS_p3: Pseudodiffusion coefficient in the subarachnoid CSF in mm2/s at time point p3

  • f SAS_p1: fluid fraction of the subarachnoid space corresponding to Dstr SAS_p1 at time point p1

  • f SAS_p2: fluid fraction of the subarachnoid space corresponding to Dstr SAS_p1 at time point p2

  • f SAS_p3: fluid fraction of the subarachnoid space corresponding to Dstr SAS_p1 at time point p3

  • fDstr SAS_p1: Product of f SAS_p1 and Dstr SAS_p1

  • fDstr SAS_p2: Product of f SAS_p2 and Dstr SAS_p2

  • fDstr SAS_p3: Product of f SAS_p3 and Dstr SAS_p3

  • Cortical CBF_p1: Cortical cerebral blood flow at time point p1

  • Cortical CBF_p2: Cortical cerebral blood flow at time point p2

  • Cortical CBF_p3: Cortical cerebral blood flow at time point p3

  • Frontal CBF_p1: Gray matter cerebral blood flow at time point p1 in the frontal lobe

  • Frontal CBF_p2: Gray matter cerebral blood flow at time point p2 in the frontal lobe

  • Frontal CBF_p3: Gray matter cerebral blood flow at time point p3 in the frontal lobe

  • Parietal CBF_p1: Gray matter cerebral blood flow at time point p1 in the parietal lobe

  • Parietal CBF_p2: Gray matter cerebral blood flow at time point p2 in the parietal lobe

  • Parietal CBF_p3: Gray matter cerebral blood flow at time point p3 in the parietal lobe

  • Temporal CBF_p1: Gray matter cerebral blood flow at time point p1 in the temporal lobe

  • Temporal CBF_p2: Gray matter cerebral blood flow at time point p2 in the temporal lobe

  • Temporal CBF_p3: Gray matter cerebral blood flow at time point p3 in the temporal lobe

  • Occipital CBF_p1: Gray matter cerebral blood flow at time point p1 in the occipital lobe

  • Occipital CBF_p2: Gray matter cerebral blood flow at time point p2 in the occipital lobe

  • Occipital CBF_p3: Gray matter cerebral blood flow at time point p3 in the occipital lobe

  • ACA-MCA CBF_p1: Cerebral blood flow in the borderzone of anterior cerebral artery and middle cerebral artery at time point p1

  • ACA-MCA CBF_p2: Cerebral blood flow in the borderzone of anterior cerebral artery and middle cerebral artery at time point p2

  • ACA-MCA CBF_p3: Cerebral blood flow in the borderzone of anterior cerebral artery and middle cerebral artery at time point p3

  • MCA-PCA CBF_p1: Cerebral blood flow in the borderzone of middle cerebral artery and posterior cerebral artery at time point p1

  • MCA-PCA CBF_p2: Cerebral blood flow in the borderzone of middle cerebral artery and posterior cerebral artery at time point p2

  • MCA-PCA CBF_p3: Cerebral blood flow in the borderzone of middle cerebral artery and posterior cerebral artery at time point p3

  • Cortical Tex_p1: Cortical exchange time at time point p1 as a measure of water transport across the endothelium

  • Cortical Tex_p2: Cortical exchange time at time point p2 as a measure of water transport across the endothelium

  • Cortical Tex_p3: Cortical exchange time at time point p3 as a measure of water transport across the endothelium

  • Frontal Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the frontal lobe gray matter

  • Frontal Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the frontal lobe gray matter

  • Frontal Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the frontal lobe gray matter

  • Parietal Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the parietal lobe gray matter

  • Parietal Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the parietal lobe gray matter

  • Parietal Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the parietal lobe gray matter

  • Temporal Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the temporal lobe gray matter

  • Temporal Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the temporal lobe gray matter

  • Temporal Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the temporal lobe gray matter

  • Occipital Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the occipital lobe gray matter

  • Occipital Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the occipital lobe gray matter

  • Occipital Tex_p3: Exchange time at time point p3  as a measure of water transport across the endothelium in the occipital lobe gray matter

  • ACA-MCA Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the anterior cerebral artery-middle cerebral artery borderzone

  • ACA-MCA Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the anterior cerebral artery-middle cerebral artery borderzone

  • ACA-MCA Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the anterior cerebral artery-middle cerebral artery borderzone

  • MCA-PCA Tex_p1: Exchange time at time point p1 as a measure of water transport across the endothelium in the middle cerebral artery-posterior cerebral artery borderzone

  • MCA-PCA Tex_p2: Exchange time at time point p2 as a measure of water transport across the endothelium in the middle cerebral artery-posterior cerebral artery borderzone

  • MCA-PCA Tex_p3: Exchange time at time point p3 as a measure of water transport across the endothelium in the middle cerebral artery-posterior cerebral artery borderzone

  • SE Frontal GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the frontal lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E 

  • SE Frontal WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the frontal lobe white matter. Signal intensities were normalized by signal intensity of Vit. E

  • SE Parietal GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the parietal lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E

  • SE Parietal WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the parietal lobe white matter. Signal intensities were normalized by signal intensity of Vit. E

  • SE Occipital GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the occipital lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E

  • SE Occipital WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the occipital lobe white matter. Signal intensities were normalized by signal intensity of Vit. E

  • SE Temporal GM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the temporal lobe gray matter. Signal intensities were normalized by signal intensity of Vit. E

  • SE Temporal WM_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the temporal lobe white matter. Signal intensities were normalized by signal intensity of Vit. E

  • SAS_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p3 in the SAS. Signal intensities were normalized by signal intensity of Vit. E

  • Ventricles_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the lateral ventricles. Signal intensities were normalized by signal intensity of Vit. E

  • ICA_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the ICA. Signal intensities were normalized by signal intensity of Vit. E

  • SS_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the SS.. Signal intensities were normalized by signal intensity of Vit. E

  • CSS_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the confluence of sinuses. Signal intensities were normalized by signal intensity of Vit. E

  • Hippocampus_p3: Signal enhancement at timepoint p3 compared to baseline timepoint p1 in the hippocamppus. Signal intensities were normalized by signal intensity of Vit. E

  • CBV Frontal GM_p2: Cerebral blood volume in the frontal lobe gray matter at timepoint p2

  • CBV Frontal WM_p2:Cerebral blood volume in the frontal lobe white matter at timepoint p2

  • CBV Parietal GM_p2: Cerebral blood volume in the parietal lobe gray matter at timepoint p2

  • CBV Parietal WM_p2: Cerebral blood volume in the parietal lobe white matter at timepoint p2

  • CBV Occipital GM_p2: Cerebral blood volume in the occipital  lobe gray matter at timepoint p2

  • CBV Occipital WM_p2: Cerebral blood volume in the occipital lobe white matter at timepoint p2

  • CBV Temporal GM_p2: Cerebral blood volume in the temporal lobe gray matter at timepoint p2

  • CBV Temporal WM_p2: Cerebral blood volume in the temporal lobe white matter at timepoint p

  • CSS/ICA_p2: Ratio of signal intensity in the confluence of sinuses to that in the internal carotid artery

  • Vit E (Pre)_p1: Raw signal intensity in the Vit E capsule at time point p1, precontrast

  • Vit E (Pre)_p2: Raw signal intensity in the Vit E capsule at time point p2, precontrast

  • Vit E (Post)_p2: Raw signal intensity in the Vit E capsule at time point p2, postcontrast

  • Vit E (post)_p3: Raw signal intensity in the Vit E capsule at time point p3, postcontrast

  • Frontal GM (Pre)_p1: Raw signal intensity in the frontal gray matter at time point p1, precontrast

  • Frontal GM (Pre)_p2: Raw signal intensity in the frontal gray matter at time point p2, precontrast

  • Frontal GM (Post)_p2: Raw signal intensity in the frontal gray matter at time point p2, postcontrast

  • Frontal GM (post)_p3: Raw signal intensity in the frontal gray matter at time point p1, postcontrast

  • Parietal GM (Pre)_p1: Raw signal intensity in the parietal  gray matter at time point p1, precontrast

  • Parietal GM (Pre)_p2: Raw signal intensity in the parietal gray matter at time point p2, precontrast

  • Parietal GM (Post)_p2: Raw signal intensity in the parietal gray matter at time point p2, postcontrast

  • Parietal GM (post)_p3: Raw signal intensity in the parietal gray matter at time point p3, postcontrast

  • Occipital GM (Pre)_p1: Raw signal intensity in the occipital gray matter at time point p1, precontrast

  • Occipital GM (Pre)_p2: Raw signal intensity in the occipital gray matter at time point p2, precontrast

  • Occipital GM (Post)_p2: Raw signal intensity in the occipital gray matter at time point p2, postcontrast

  • Occipital GM (post)_p3: Raw signal intensity in the occipital gray matter at time point p3, postcontrast

  • Temporal GM (Pre)_p1: Raw signal intensity in the temporal gray matter at time point p1, precontrast

  • Temporal GM (Pre)_p2: Raw signal intensity in the temporal gray matter at time point p2, precontrast

  • Temporal GM (Post)_p2: Raw signal intensity in the temporal gray matter at time point p2, postcontrast

  • Temporal GM (post)_p3: Raw signal intensity in the temporal gray matter at time point p3, postcontrast

  • Frontal WM (Pre)_p1: Raw signal intensity in the frontal white matter at time point p1, precontrast

  • Frontal WM (Pre)_p2: Raw signal intensity in the frontal white matter at time point p2, precontrast

  • Frontal WM (Post)_p2: Raw signal intensity in the frontal white matter at time point p2, postcontrast

  • Frontal WM (post)_p3: Raw signal intensity in the frontal white matter at time point p3, postcontrast

  • Parietal WM (Pre)_p1: Raw signal intensity in the parietal white matter at time point p1, precontrast

  • Parietal WM (Pre)_p2: Raw signal intensity in the parietal white matter at time point p2, precontrast

  • Parietal WM (Post)_p2: Raw signal intensity in the parietal white matter at time point p2, postcontrast

  • Parietal WM (post)_p3: Raw signal intensity in the parietal white matter at time point p3, postcontrast

  • Occipital WM (Pre)_p1: Raw signal intensity in the occipital white matter at time point p1, precontrast

  • Occipital WM (Pre)_p2: Raw signal intensity in the occipital white matter at time point p2, precontrast

  • Occipital WM (Post)_p2: Raw signal intensity in the occipital white matter at time point p2, postcontrast

  • Occipital WM (post)_p3: Raw signal intensity in the occipital white matter at time point p3, postcontrast

  • Temporal WM (Pre)_p1: Raw signal intensity in the temporal white matter at time point p1, precontrast

  • Temporal WM (Pre)_p2: Raw signal intensity in the temporal white matter at time point p2, precontrast

  • Temporal WM (Post)_p2: Raw signal intensity in the temporal white matter at time point p2, postcontrast

  • Temporal WM (post)_p3: Raw signal intensity in the temporal white matter at time point p3, postcontrast

  • SAS (Pre)_p1: Raw signal intensity in the SAS at time point p1, precontrast

  • SAS (Pre)_p2: Raw signal intensity in the SAS at time point p2, precontrast

  • SAS (Post)_p2: Raw signal intensity in the SAS at time point p2, postcontrast

  • SAS (post)_p3: Raw signal intensity in the SAS at time point p3, postcontrast

  • Ventricles (Pre)_p1: Raw signal intensity in the ventricles at time point p1, precontrast

  • Ventricles (Pre)_p2: Raw signal intensity in the ventricles at time point p2, precontrast

  • Ventricles (Post)_p2: Raw signal intensity in the ventricles at time point p2, postcontrast

  • Ventricles (post)_p3: Raw signal intensity in the ventricles at time point p3, postcontrast

  • ICA (Pre)_p1: Raw signal intensity in the internal carotid artery at time point p1, precontrast

  • ICA (Pre)_p2: Raw signal intensity in the internal carotid artery at time point p2, precontrast

  • ICA (Post)_p2: Raw signal intensity in the internal carotid artery at time point p2, postcontrast

  • ICA (post)_p3: Raw signal intensity in the internal carotid artery at time point p3, postcontrast

  • SS (Pre)_p1: Raw signal intensity in the sagittal sinus at time point p1, precontrast

  • SS (Pre)_p2: Raw signal intensity in the sagittal sinus at time point p2, precontrast

  • SS (Post)_p2: Raw signal intensity in the sagittal sinus at time point p2, postcontrast

  • SS (post)_p3: Raw signal intensity in the sagittal sinus at time point p3, postcontrast

  • CSS (Pre)_p1: Raw signal intensity in the confluence of sinuses at time point p1, precontrast

  • CSS (Pre)_p2: Raw signal intensity in the confluence of sinuses at time point p2, precontrast

  • CSS (Post)_p2: Raw signal intensity in the confluence of sinuses at time point p2, postcontrast

  • CSS (post)_p3: Raw signal intensity in the confluence of sinuses at time point p3, postcontrast

  • Hippocampus (Pre)_p1: Raw signal intensity in the hippocampus at time point p1, precontrast

  • Hippocampus (Pre)_p2: Raw signal intensity in the hippocampus at time point p2, precontrast

  • Hippocampus (Post)_p2: Raw signal intensity in the hippocampus at time point p2, postcontrast

  • Hippocampus (post)_p3: Raw signal intensity in the hippocampus at time point p3, postcontrast

 

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