Published March 5, 2025 | Version 1.0.0

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

  • 1. EDMO icon Institute for Systems Biology

Description

Datasets accompanying the publication "Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma" (preprint, publication).

See also the code associated with the paper.

scRNAseq

Data is in `h5ad` format , i.e. count matrices (cells x genes) for 

  • `EsophagusAtlas_primary_dataset.h5ad`: the primary cohort
  • `EsophagusAtlas_validation_dataset.h5ad`:the validation cohort
  • `EsophagusAtlas_primary_and_validation_dataset.h5ad`: primary+validation cohort merged

CODEX

Data is in `h5mu` format, i.e. multiple samples stacked as `modalities`. 28 samples total.

Files

Files (8.6 GB)

Name Size
md5:41448df2ff8f8710c1749f7c9d3f7f5e
450.2 MB Download
md5:ee6a06ff33dc1e46908e0b91adf9b106
4.1 GB Download
md5:521477c76844a1bb9921a0d362c743dc
2.5 GB Download
md5:3e2ffcca143d058c997b51cbe8f32dee
1.6 GB Download

Additional details

Related works

Is published in
Publication: 10.1016/j.devcel.2025.06.034 (DOI)

Software

Repository URL
https://github.com/redst4r/crukiopy_release
Programming language
Python
Development Status
Active