Summary Statistics: Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases
Authors/Creators
Researcher (33):
- Camacho, Niedzica
- Shea, Patrick
- Stopsack, Konrad
- Joseph, Vijai
- Burren, Oliver
- Dhindsa, Ryan
- Nag, Abhishek
- Berchuck, Jacob
- O'Neill, Amanda
- Abbasi, Ali
- Zoghbi, Anthony
- Alegre-Díaz, Jesus
- Kuri-Morales, Pablo
- Berumen, Jaime
- Tapia-Conyer, Roberto
- Emberson, Jonathan
- Torres, Jason
- Collins, Rory
- Wang, Quanli
- Goldstein, David
- Matakidou, Athena
- Haefliger, Carolina
- Anderson-Dring, Lauren
- March, Ruth
- Jobanputra, Vaidehi
- Dougherty, Brian
- Carss, Keren
- Petrovski, Slavé
- Kantoff, Philip
- Offit, Kenneth
- Mucci, Lorelei
- Pomerantz, Mark
- Fabre, Margarete
Description
Exome wide gene and single variant level summary statistics associated with the Nature Communications article "Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases".
Gene Level Association Files
gene_level_prostate_cancer_risk.txt: gene-level summary statistics for assocation with prostate cancer risk (case Vs controls)
gene_level_prostate_cancer_severity.txt: gene-level summary statistics for assocation with prostate cancer severity (aggressive prostate cancer Vs non-aggressive prostate cancer)
gene_level_prostate_cancer_agg_ctrl.txt: gene-level summary statistics for assocation of aggressive prostate cancer Vs controls
Columns
Gene Name
Gene ENSG - Ensembl gene ID
CA_model - collapsing analysis qualifying variant model (as in Supplementary Data 1 of article)
CMH_P - meta analysis P-value
CMH_OR - meta analysis odds ratio
CMH_OR_LCI - meta analysis odds ratio lower confidence interval
CMH_OR_UCI - meta analysis odds ratio upper confidence interval
Total Qual Cases - number of cases carrying a qualifying variant
Total Unqual Cases - number of cases not carrying a qualifying variant
Total Qual Ctrls - number of controls carrying a qualifying variant
Total Unqual Ctrls - number of controls not carrying a qualifying variant
Single Variant level Association File
single_variant_prostate_cancer_risk.txt - single variant level summary statistics for assocation with prostate cancer risk (case Vs controls)
Columns
chr - chromosome
pos - genomic position
effect_allele
other_allele
P - meta analysis P-value
direction - direction of effect in individual cohorts (100KGP, MCPS, UKB_SAS, UKB_AFR, UKB_EUR, FinnGen).