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Published January 2025 | Version v1
Dataset Open

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - data repository

Authors/Creators

  • 1. ROR icon Heidelberg Institute for Stem Cell Technology and Experimental Medicine
  • 2. ROR icon German Cancer Research Center
  • 3. EDMO icon University of Heidelberg
  • 4. ROR icon National Center for Tumor Diseases
  • 5. Charite - Berlin University of Medicine
  • 6. ROR icon Max Delbrück Center
  • 7. ROR icon Berlin Institute of Health at Charité - Universitätsmedizin Berlin
  • 8. ROR icon DKFZ-ZMBH Alliance

Description

Single-cell RNA sequencing data from five single-HSC-derived murine hematopoietic systems, as well as two polyclonal controls. The resulting clonally-resolved hematopoietic bone marrow atlas (scBM_atlas.rds) consists of 76,863 high-quality cells and covers all major hematopoietic cell types, including differentiation tracks (slingshot.rds) from the most immature HSCs to all lineage-committed progenitors (HSPCs.rds) and their continued maturation into blood and immune cells. 

Files

Files (2.4 GB)

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md5:6e15b76d6d420bd440e75f72a5ce1786
690.5 MB Download
md5:cf65103739762c7c4aac7288da74d1df
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md5:88d27bcf54956c2c115c9759ff7b3319
515.5 MB Download