Data described in the article "Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico."

Published December 13, 2024 | Version v1

Dataset Open

Single [Ca2+] screen for recoupling

Many compounds re-couple many mutations.

Effects of dobutamine on cardiac myocyte contractility.

Lusitropy and the effect of small molecules measured in cardiomyocytes

Preferred structure of small molecules with atoms and rings labelled.

Comparison of the effects of EGCG and ECG on the distribution of helix A/B and interdomain angles.

CCPtraj analysis of ligand binding, ligand hotspots on representative structures, link to movies

snapshots from single 1500ns MD trajectories, 7500 total fram

Files

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Data Sheet 1_Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscl.pdf md5:8d8c39bd4e4cb97c84e411917d3f01e7	2.0 MB	Preview Download

British Heart Foundation
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British Heart Foundation
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Wellcome Trust
108908/Z/15/Z
Ministry of Education Youth and Sports
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