Report Open Access
The human papillomavirus (HPV) vaccine and Hepatitis B vaccine (HBV) are recombinant vaccines produced by genetically modifying yeast ( Saccharomyces cerevisiae). The vaccines therefore contain yeast proteins ranging from 7 mcg up to 5% of total protein content. The target proteins are weakly immunogenic. The human immune system has evolved sophisticated checks and balances to selectively attack danger associated proteins and pathogen associated proteins while tolerating self and harmless proteins. This mechanism is the reason why harmless target proteins in vaccines are weakly immunogenic. Vaccinologists defeat the immune system's checks and balances and force an immune response directed against these weakly immunogenic target proteins, by using immunological adjuvants. The result is a robust immune response directed against target proteins which makes the vaccines effective. However, this boosted immune response is not limited to the target proteins alone.
The robust immune response is also directed at non-target proteins (yeast proteins in this case) thus resulting in numerous off-target immune responses. Numerous epidemiological studies and a meta analysis have linked yeast containing vaccines to autoimmune disorders. Here, bioinformatics analysis adds mechanistic evidence demonstrating that these vaccines can produce numerous autoimmune disorders due to molecular mimicry between yeast proteins and human self proteins. Pandemrix vaccine induced narcolepsy, an autoimmune disorder, due to molecular mimicry between H1N1 nucleoproteins in the vaccine and the human hypocretin receptor 2. This failure mechanism can affect all vaccines. The ultimate solution is to remove all non-target proteins from vaccines.