Poster Open Access

Understanding the pathogenic mechanism of ACVR1 mutations in Diffuse Intrinsic Pontine Glioma

Brown, Elizabeth; Farnie, Gillian; Bullock, Alex

A research poster outlining the planned experiments and preliminary results of a research project titled 'Understanding the pathogenic mechanism of ACVR1/ALK2 mutations in Diffuse Intrinsic Pontine Glioma (DIPG)'. The subheadings include BMP signalling mechanisms, epigenetic screening, migration assays and CRISPR-Cas9 knockout of mutant ACVR1.

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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