Bidirectional Mendelian Randomization Study Reveals Causal Associations Between Allergic Rhinitis and Asthma
Authors/Creators
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1.
State Key Laboratory of Respiratory Disease
- 2. National Clinical Research Center for Respiratory Disease
- 3. Guangzhou Institute of Respiratory Health
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4.
First Affiliated Hospital of Guangzhou Medical University
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5.
First Affiliated Hospital of Jinan University
Description
This dataset accompanies the study "Analysis of Causal Association between Allergic Rhinitis and Asthma," which explores the bidirectional causal relationship between allergic rhinitis and asthma using a two-sample Mendelian randomization (MR) approach. The primary data sources include genome-wide association studies (GWAS) data on allergic rhinitis from the UK Biobank (UKB) with 18,934 cases and 64,595 controls, and asthma data from a Finnish cohort with 20,629 cases and 135,449 controls.
Content:
- SNP Data: The dataset includes selected single nucleotide polymorphisms (SNPs) used as instrumental variables (IVs) in MR analysis.
- MR Analysis Results: Inverse variance weighting (IVW), MR-Egger, and other MR analysis methods' results.
- Heterogeneity and Pleiotropy Tests: Details on Cochrane’s Q test, MR-PRESSO for pleiotropy, and leave-one-out sensitivity analysis.
Purpose and Scope: The study aims to quantify the causal relationship between allergic rhinitis and asthma, addressing the prevalence and co-occurrence of these conditions. The findings support the hypothesis of a bidirectional association, with implications for prevention and treatment strategies.