Losses in crop yield due to invasive insects, weeds, pathogens, and herbivores cost trillions of dollars per year globally. To prevent further spread of invasive agricultural pest species, continuous monitoring and prevention are crucial. Once introduced, however, assessing the impact of an invasive pest on agricultural production and testing management strategies are essential. The green iguana (Iguana iguana), a globally widespread invasive herbivore, is considered a possible agricultural pest although no quantitative data on its impact are available. In this study, we evaluated the impact of the invasive green iguana on cucumber (Cucumis sativus, var. Dasher II) and lettuce (Lactuca sativa, var. Black-seeded Simpson) yield by testing the efficacy of two management strategies – Neem-based pesticide and mesh fencing – compared to open field cultivation in Puerto Rico. Mesh fencing led to 20% more growth and doubled cucumber yield compared to open field cultivation, while spraying Neem led to an 18% increase in plant growth but no effect on cucumber yield. We found no difference in lettuce growth or yield among treatment and control plots. This study supports categorizing the green iguana as an invasive agricultural pest species and demonstrates the reptile's potential to reduce crop yield. It also shows that Neem application at the manufacturer's suggested concentration is not an effective mitigation technique for reducing crop loss due to green iguana herbivory. Government agencies in regions where the green iguana has the potential to be introduced should consider the species a threat to food production when developing monitoring programs and drafting regulations.