TREATMENT WITH SEMECARPUS ANACARDIUM EXTRACT CURTAILS CISPLATIN INDUCED NEPHROTOXICITY AND OXIDATIVE STRESS IN MICE

The nephroprotective evaluation of fruits of Semecarpus anacardium has not been reported so far. It is mostly evaluated for their anti-inflammatory, hepatoprotective and anticancer activities. The present study was focused on the effect of hydroalcoholic extracts of S. anacardium (HASA) against cisplatin induced nephrotoxicity in mice. Administration of cisplatin in mice has resulted in acute renal injury which is evident from the biochemical and histological studies. Pretreatment with higher doses (400mg/kg) of HASA significantly reversed the adverse effect of cisplatin on kidney weight, serum urea, creatinine and uric acid indicating their nephro-protective effect.  HASA have exhibited significant effect on the regulation of K⁺ ions in cisplatin administered mice. The antioxidant effect of HASA is evident from their significant effect on CAT, GSH-px and lipid peroxidation activities. The histopathological studies revealed that HASA has good protective effect to overcome the cisplatin induced structural damages on kidney.

Keywords: Cisplatin, Histopathology, Nephroprotective, Oxidative stress, Toxicity