Published September 3, 2024 | Version Economic Adversity and fear conditioning-V1.0

Economic Adversity and dynamic neural changes during fear conditioning

  • 1. ROR icon Guangzhou University

Description

 

The "depression_anxiety_symptoms.RData" file contains data on depression and anxiety across four time points, which can be used for trajectory analysis.

The "fp_use_dataframes.RData" file contains data from four blocks of fear learning, specifically including functional activation analysis data of five key regions of interest (ROIs) under conditions such as CS+, CS-, and CS+>CS-, learning slope data, and data for moderation analysis.

The "fp_use_dataframes-fc-analysis.RData" file contains data from four blocks of fear learning, specifically including generalized PPI connectivity analysis data under conditions such as CS+, CS-, and CS+>CS-.

The "BLA_slope_trajectory_analysis.csv" file contains data that can be used to examine the relationships between brain activity data, inflammation composite scores, and symptom trajectory development.

The "code_in_study.R" file contains code for linear mixed model analysis (including three-way and two-way interactions), between-group difference analysis of learning slopes, and related plotting code.

The "ANOVA-plot_code.R" file contains code for interaction analysis between economic adversity and background factors (such as childhood maltreatment, subjective SES), post-hoc between-group difference tests, and plotting.

The "LCGMs-model fit-comparison.R" file contains code for comparing the differences between unconditional models, linear models, and quadratic change models in trajectory analysis.

The "trajectory_analysis.R" file contains code for examining the relationship between the basolateral amygdala's learning slope and depression/anxiety trajectories, as well as code for testing the mediating effect of anxiety trajectories between the basolateral amygdala's learning slope and inflammation.

Files

BLA_slope_trajectory_analysis.csv

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