Published August 29, 2024 | Version v1
Dataset Open

Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering - Underlying data

Authors/Creators

  • 1. ROR icon University of Southampton
  • 2. μ-VIS X-ray Imaging Centre
  • 3. ROR icon Aristotle University of Thessaloniki
  • 4. Netherlands Organization for Applied Scientific Research (TNO)

Description

Underlying microfocus CT and XCT image-based modeling of Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering by 

Angelos Gkaragkounis a,b,*, Konstantina Chachlioutaki a,c, Orestis L. Katsamenis d,e,, Fernando Alvarez-Borges d, Savvas Koltsakidis f, Ioannis Partheniadis a, Nikolaos Bouropoulos g,h Ioannis S. Vizirianakisi, Dimitrios Tzetzis f, Ioannis Nikolakakis a, Chris H. J. Verhoeven b, Dimitrios G. Fatouros a,c,*, Kjeld J. C. van Bommel b,*

  • a Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece
  • bThe Netherlands Organization for Applied Scientific Research (TNO), Eindhoven 5656 AE, The Netherlands
  • c1 μ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK 
  • c2 Institute for Life Sciences, University of Southampton, University Road, Highfield, Southampton SO17 1BJ, UK
  • e Department of Materials Science, University of Patras, Patras, 26504 Rio, Greece
  • f Laboratory of Pharmacology, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GR 54124, Greece
  • g Digital Manufacturing and Materials Characterization Laboratory, School of Science and Technology, International Hellenic University, Thessaloniki, 57001, Greece

Table of contents

Data Repository Index

This repository contains all XCT and Permeability analysis datasets, exported images, and multemedia associated with this paper. Below is a detailed description of each file:

1. Analysis and Raw Data Files

  • Analysis.opju (1.06 MB)
    Origin project file containing detailed data plots and analysis results of the histograms depicting the distribution of local thickness values

  • Analysis.xlsx (551.24 KB)
    Spreadsheet with numerical data summaries, including porosity percentages, pore size distributions, and local thickness values.

  • 3739_spike2_1096x1092x89_1x8bit.raw (1.07 GB)
    Raw μCT data of the spiked object in 8-bit format.

  • spike1_AnalysisOpenPNM.ORSSession (1.93 GB)
    OpenPNM Dragonfly(R) session file for porosity network analysis.

  • spike2-AvizoProject.zip (473.91 KB)
    Avizo project file for 3D Permeability analysis and visualisation.

2. Processed Data and Visualisations

  • Material-Pore-PhaseThickness-5-6SpikesHistograms.zip (462.09 KB)
    Histogram data for thickness distributions across the material and pore phases.

  • PHAR11131-DOSF_5Spikes_Vol-03.png (613.55 KB)
    3D photorealistic representation of the 5-spike object.

  • PHAR11144-DOSF_6Spikes_poreThickness-2D-01.png (448.17 KB)
    2D slice showing local thickness mapping of the pore phase in the 6-spike object.

  • PHAR11144-DOSF_6Spikes_3D-01.png (523.23 KB)
    3D volume rendering of the 6-spike object.

  • Permeability_6Spikes_PHAR11144-DOSF.png (908.02 KB)
    Visual summary of permeability analysis results.

  • PHAR11131-DOSF_5spikes_thickness-3D-02.png (1.38 MB)
    3D volume rendering of local thickness distribution in the 5-spike object.

  • PHAR11144-DOSF_6Spikes_3D-VolThickness-02.png (1.11 MB)
    3D volume thickness map for the 6-spike object.

3. Animation Files

  • Permeability_6Spikes_PHAR11144-DOSF_animation2.mp4 (17.88 MB)
    Animation showing the permeability flow paths and local thickness analysis in the 6-spike object.

4. Image Processing Workflows

  • PHAR11144-DOSF_6Spikes_2D-SegmWorkflow.zip (993.10 KB)
    Segmentation workflow detailing the steps for thresholding, mask creation, and watershed-based separation.

Note:

All raw data and processed files are provided for transparency and reproducibility.

Files

PHAR11131-DOSF_5Spikes_thickness-3D-02.png

Files (3.5 GB)

Name Size
md5:80abafd1a1a20f89d0b0cafbdd192188
1.1 GB Download
md5:190968c5ce1b9a763491cf8a7dac1fae
1.1 MB Download
md5:463b09a2316afd97054ef03ca071c7b8
551.2 kB Download
md5:64215661538e810b91dffeb9f6ad0047
462.1 kB Preview Download
md5:83d3f4f3f2d8944d0ffcf8aab1691f52
908.0 kB Preview Download
md5:53fd516de508599180597f1e6f4b3668
17.9 MB Preview Download
md5:f34cf30a7bc7de038a6015699fa72e6a
673.4 kB Preview Download
md5:e7519fa134e29fc217581fa49d56efca
1.4 MB Preview Download
md5:430fc3530725b3cb91da4aa26d2236c0
613.5 kB Preview Download
md5:b2f349472626fa7cc15937d64923a613
993.1 kB Preview Download
md5:835ee0bd4966572573133e62785ce9b1
523.2 kB Preview Download
md5:a2c514130b595e62e03c4738d2cc493d
1.3 MB Preview Download
md5:48c2d5f008c454cffc933c7e7d94add4
1.1 MB Preview Download
md5:54bdff989a5d1767fda3ba50018903ef
448.2 kB Preview Download
md5:b5037bb9f217663394d011183f700a99
1.9 GB Download
md5:5a9a621fa49f1cd04d86b90263acac3f
473.9 MB Preview Download

Additional details

Related works

Is supplement to
Publication: 10.1021/acsbiomaterials.4c02038 (DOI)