Published August 15, 2018 | Version v1
Journal article Open

Circadian epigenetics of Alzheimer's disease

Authors/Creators

  • 1. Samara State Medical University

Description

Interdisciplinary and interdepartmental interaction, gerontoneurological and gerontopsychiatric combined neurorehabilitation of Alzheimer’s disease (AD), the combination of healthy lifestyle, physical activity, functional nutrition, circadian rhythms and maintenance of the activity of “cognitive brain” on the 4P medicine platform will create a medical and economic basis for individual and regional increase in human life expectancy. The paper shows that the presence of the specific mutations in the genes of predisposition to AD increases the risk of developing the disease. Using, alongside with hybrid and combined methods of managing the “cognitive brain”, IT-technologies and new-generation automatic analysis of full–genome sequencing in modern medical–diagnostic process improve the quality of medical care. The study of genetic and epigenetic features of neurodegeneration will allow introducing more effective methods of treatment of age-dependent cognitive disorders into clinical practice. Circadian epigenetics and modern chronomedicine are innovative fields of science that study the complex influence of cosmic, biophysical, biological, genetic, medical and social factors on the human body.

Files

Волобуев А. Н., Романчук Н. П., Пятин В. Ф. .pdf

Files (974.7 kB)

Additional details

Identifiers

URL
http://www.bulletennauki.com/volobuev

Related works

Is compiled by
2414-2948 (ISSN)

References

  • Volobuev, A. N., Pyatin, V. F., & Romanchuk, N. P. (2017). Preservation of species and evolution of human cognitive abilities. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 19(3), 112-124.
  • Volobuev, A. N., Romanchuk, N. P., Pyatin, V. F. (2016). Cognitive longevity and methods of its increase. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 18(10), 83-84.
  • Pyatin, V. F., & Romanchuk, N. P. (2017). Gerontological and geriatric aspects of human brain neuroplasticity. Klinicheskie i fundamentalnye aspekty gerontologii. Ed. G. P. Kotelnikov, S. V. Bulgakova. Samara, Samar. Gos. honey. Univ., 371-385.
  • Nikitin, O. L., Pyatin, V. F., Romanchuk, N. P., Volobuev, A. N., Sirotko, I. I., Kuznetsov, S. I., Sivakova, E. V., Kurmaev, D. P., Kulidzhanov, A. A., Arsyutina, O. V., & Mostovoi, L. Ya. (2017). Hybrid and combined methods of neuroimaging. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 19(11), 200-208.
  • Nikitin, O. L., Pyatin, V. F., Romanchuk, N. P., Volobuev, A. N., Sirotko, I. I., Kurmaev, D. P., & Davydkin, I. L. (2017). Neurophysiology of aging. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 19(12), 246-251.
  • Pyatin, V., Volobuev, A., Romanchuk, N., Shchukin, Yu., Bulgakova, S., & Nikitin, O. (2018). Senile dementia of Alzheimer's type: neurophysiological and geriatric aspects. Bulletin of Science and Practice, 4(6), 53-70.
  • Pyatin, V., Romanchuk, N., & Volobuev, A. (2017). Neurovisualization and neuroplasticity: innovations in diagnosis and treatment. Bulletin of Science and Practice, (9), 51-61.
  • Volobuev, A. N., Zakharova, N. O., Romanchuk, N. P., Romanov, D. V., Romanchuk P. I., & Adyshirin-Zade, K. A. (2016). Modern principles of geriatric analysis in medicine. Uspekhi gerontologii, 29(3), 461-470.
  • Romanchuk, P. I. (2015). Demographic aging: modern challenges and solutions. Science and practice: partnership and implementation of the national health strategy in the region. Samara, 156-162.
  • Dyukov, E. V., Bachinskaya, N. Yu., Kholin, V. A., Kolyada, A. K., & Vayserman, A. M. (2015). Genetic and epigenetic determinants of Alzheimer's disease. Uspekhi gerontologii, 28(2), 299-306.
  • Cacabelos, R. (2016). Epigenetics of brain disorders: the paradigm of Alzheimer's disease. J Alzheimers Dis Parkinsonism, 6(229), 2161-0460.
  • Romanchuk, N. P., Pyatin, V. F., & Volobuev, A. N. (2017). Neurophysiological and biophysical principles of neuroplasticity. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 19(2), 97-101.
  • Volobuev, A. N., Romanchuk, N. P., & Pyatin, V. F. (2016). Circadian biophysics and neuroplasticity. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 18(8), 79-83.
  • Romanchuk, N. P., Pyatin, V. F., & Volobuev, A. N. (2017). Neurophysiological and biophysical principles of neuroplasticity. Zhurnal nauchnykh statei Zdorovie i obrazovanie v XXI veke, 19(2), 97-101.
  • Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, Ch., & al. (2008). SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation. Cell., 134, 317-328.