SYNTHESIS OF ACETYLENE ALCOHOLS IN DIFFERENT CATALYTIC SYSTEMS

In this study, with the participation of such complex catalytic systems as 3,3'-Ph₂BINOL-2Li/Ti(OⁱPr)₄/Et₂Zn and Zn(OTf)₂/TBAF•3H₂O, some ketones with a carbonyl group in the molecule - cyclopentanone, cyclohexanone, camphor , adamantanone, methyl butyl ketone, methyl ethyl ketone, methyl isopropyl ketone, methyl tert-butyl ketone, acetophenone, methyl p-tolyl ketone, methyl mesityl ketone, methyl β-naphthyl ketone, methyl furyl ketone, methyl thienyl ketone, methyl pyridinyl ketone and methyl 2-chlorothiophenyl ketone terminal alkynes – acetylene, hexine, octine and phenylacetylene by alkynylation reaction acetylene alcohols with high biological activity were synthesized. The relative efficiency of acetylenic alcohols synthesis was established based on the structure, nature, and chemical activity of ketone molecules, the nucleophilic addition reaction of ketones, and their influence on the product yield.