Exogenous Surfactant Therapy Affects Short-Term Survival in Patients With Acute Respiratory Distress Syndrome: Retrospective Analysis of 137 Fatal Cases
Authors/Creators
- 1. State Institution “Crimea State Medical University named after S.I. Georgievsky”, Simferopol, Crimea Republic, Russian Federation
Description
Novikov N. Y., Potapov A. L., Boiarkina A. V. Exogenous Surfactant Therapy Affects Short-Term Survival in Patients With Acute Respiratory Distress Syndrome: Retrospective Analysis of 137 Fatal Cases. Journal of Health Sciences. 2014;4(14):121-126. ISSN 1429-9623 / 2300-665X.
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A121-126
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A121-126
https://pbn.nauka.gov.pl/works/512346
DOI: 10.5281/zenodo.13329
http://dx.doi.org/10.5281/zenodo.13329
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 10.12.2014.
Exogenous Surfactant Therapy Affects Short-Term Survival in Patients With Acute Respiratory Distress Syndrome: Retrospective Analysis of 137 Fatal Cases
Novikov N. Y., Potapov A. L., Boiarkina A. V.
State Institution “Crimea State Medical University named after S.I. Georgievsky”, Simferopol, Crimea Republic, Russian Federation
Summary
The objective of this study is the evaluation of exogenous surfactant therapy impact on short-term survival in patients with acute respiratory distress syndrome (ARDS). Retrospective analysis of 137 fatal ARDS cases has been conducted. The period from ARDS onset till fatal outcome in patients with conventional treatment was 2 (1-4) days, in patients with additional exogenous surfactant administration – 5 (3-10) days (p<0.001). The surfactant therapy was a significant predictor of surviving (HR=0.38; 95% CI 0.249-0.579; p<0.001). It has been concluded that exogenous surfactant therapy may increase short-term survival in ARDS patients.
Key words: ARDS, exogenous surfactant therapy.
Notes
Files
2014_4_14_121-126_2480_979.pdf
Additional details
Related works
References
- 1. Raghavendran K., Willson D., Notter R.H. Surfactant Therapy of ALI and ARDS. Crit Care Clin. 2011; 27: 525-59.
- 2. Meng H., Sun Y., Lu J. et al. Exogenous surfactant may improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome: a meta-analysis of 9 clinical trials. J Cardiothorac Vasc Anesth. 2012; 26: 849-856.
- 3. Taut F.J., Rippin G., Schenk P. et al. A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest. 2008; 134: 724-732.
- 4. ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012; 307: 2526-33.
- 5. Potapov A.L. The state of the pulmonary surfactant system in patients with the acute pulmonary damage syndrome. Klinichna hirurgija. 2000; 9: 29-31.
- 6. Varisco B.M., Palmatier C.M., Alten J.A. Reversal of intractable hypoxemia with exogenous surfactant (calfactant) facilitating complete neurological recovery in a pediatric drowning victim. Pediatr Emerg Care. 2010; 26: 571-3.
- 7. Fettah N., Dilli D., Beken S. et al. Surfactant for acute respiratory distress syndrome caused by near drowning in a newborn. Pediatr Emerg Care. 2014; 30: 180-1.
- 8. Birkun A.A. Administration of Antimicrobials into Respiratory Tract: Methods to Improve Efficacy in the Treatment of Hospital-Acquired Pneumonia. Clinical Microbiology and Antimicrobial Chemotherapy. 2014; 3: 185-94.