Journal article Open Access

Purification and crystallisation of ALK2 (r206H) in complex with FKBP12 and M4KPharma compounds

Williams, E. P.; Bullock, A. N.

Purification of ALK2 containing the R206H mutation, and complex assembly with FKBP12. 

Crystallisation with compounds M4K2009, M4K3003 and M4K3007 in coarse screens at 20ºC and 4ºC

 

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Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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