Published August 2, 2018
| Version v1
Journal article
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Purification and crystallisation of ALK2 (r206H) in complex with FKBP12 and M4KPharma compounds
Description
Purification of ALK2 containing the R206H mutation, and complex assembly with FKBP12.
Crystallisation with compounds M4K2009, M4K3003 and M4K3007 in coarse screens at 20ºC and 4ºC
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Notes
Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
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Zenodo purification and crystallisation of ALK2 R206H.pdf
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