Comparison of accelerated collagen cross linking & conventional collagen cross linking in management of keratoconus: An interventional study

Abstract— Keratoconus is a disease of corneal and is a growing disease in the young population of today and in recent years many new modalities of treatment have come up to try and stop its progression in the early stages. Corneal collagen cross linking (CXL) is one of those modality. there are two type of  CXL surgeries one is conventional other one is accelerated one. This intervention study was conducted on 40 patients and 60 eyes compare the outcome of conventional CXL (30 eyes) and accelerated CXL(30 eyes) in treatment of Keratoconus. It was found that there was no significant difference in change in various parameters like Log MAR best corrected visual acuity (BCVA) on Snellen’s Chart, Spherical Equivalent (SEQ), Kmax (D) and Central Corneal Thickness (CCT) after 3 months as well as after 6 months in both the type of modalities. It was conclude from this study that accelerated CXL shows comparable results with conventional CXL in arresting the progression of mild KC, but long-term follow-up evaluation is warranted to delineate any difference in the clinical and topographical effect between the conventional and accelerated protocols.