PHYTOCHEMICAL SCREENING AND ANALGESIC ACTIVITY ON COCCINIA GRANDIS
Authors/Creators
- 1. * 1 Principal & Professor, Department of Pharmacy, Brilliant Grammar School Educational Society, Group of Institutions Integrated Campus (Faculty of Engineering & Faculty of Faculty), Abdullapurmet, Hyderabad, Telangana, INDIA. 2 Assistant Professor, Department of Pharmacy, Brilliant Grammar School Educational Society, Group of Institutions Integrated Campus (Faculty of Engineering & Faculty of Faculty), Abdullapurmet, Hyderabad, Telangana, INDIA.
Description
ABSTRACT
In the present study, the analgesic effect of the aqueous extract of coccinia grandis whole plant was investigated. The hydroalcoholic extracts of coccinia grandis whole plant were ingested orally (p.o.) in two different doses, 200 and 400 mg/kg body weight. The analgesic activity of the aqueous effect of coccinia grandis was evaluated in Whister Albino rat by using Analgesiometer and Eddys hot plate method and compared with the standard, Diclofenac (10 mg/kg body weight). The results showed that coccinia grandis has significant (p<0.01) reduction in the paw licking for (400 mg/kg), tail flicking for (200 mg/kg) and diclofenac (10 mg/kg) when compared to control. These results expressing that the extracts would possess analgesic properties. All these effects and the changes in the behavioural activities could be suggested as contributory effects to the use of coccinia grandis whole plant in the management of inflammation and painful conditions.
KEYWORDS: Coccinia Grandis, Analgesic, Diclofenac, Aqueous extract and Phytochemical Screening.