CYTOTOXICITY AND ANTIBACTERIAL ACTIVITY OF THE 70% ETHANOLIC EXTRACT OF THE STEM BARK OF PIPTADENIASTRUM AFRICANUM HOOK (FABACEAE).

In order to justify the traditional use of medicinal plants in the treatment of skin infections, Piptadeniastrum africanum Hook (Fabaceae), a plant used in traditional medicine in the Sassandra Region, in the treatment of bacterial diseases has been investigated. The 70% ethanolic extract of the stem bark was tested on six bacterial strains including three Staphylococcus aureus and three Pseudomonas aeruginosa as well as its cytotoxicity on HFF cells (Human Foreskin Fibroblasts). The dilution method in solid and liquid medium was used. The results show that the 70% ethanolic extract is active on all six bacterial strains with MIC ranging from 0.04 to 6.25 mg / mL. The 70% ethanolic extract showed a fungicidal action on all the strains studied and was not cytotoxic on the HFF cells studied. These results justify the traditional use of this plant against skin infections. Keywords: bacterial infection, ethanolic extract, Haut-Sassandra, Piptadeniastrum africanum,