Mucosoprotective effect of lysozyme-forte in rats that received super-oxidized sunflower oil
Authors/Creators
- 1. Lviv National Medical University named after Danylo Galytskij
- 2. Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine
Description
Labush Iu. Z., Markov A. V., Zubachik V. М., Levitsky A. P. Mucosoprotective effect of lysozyme-forte in rats that received super-oxidized sunflower oil. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2018;2(79):75-79. ISSN 0049-6804.
DOI http://dx.doi.org/10.5281/zenodo.1307442
http://www.herald.com.ua
UDК 616.153:588.152:616.633:612.31
MUCOSOPROTECTIVE EFFECT OF LYSOZYME-FORTE In RATS THAT RECEIVED SUPER-OXIDIZED SUNFLOWER OIL
Iu. Z. Labush, A. V. Markov, V. М. Zubachik, A. P. Levitsky
Lviv National Medical University named after Danylo Galytskij;
State Establishment «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine»
e-mail: flavan.ua@gmail.com
Abstract
The objective: To determine the therapeutic and prophylactic effect of the new complex antidysbiotic drug Lysozyme –forte with the introduction of the body super-oxidized of sunflower oil (SOSO). Materials and methods: As a drug of comparison, the flavans-containing Quertulin was used, which, like Lysozyme –forte, was administered with food at a dose of 300 mg/kg daily, starting from the 31st day of the experiment. SOSO was administered with feed at a dose of 1 ml/rat for 2,5 month. The activity of elastase, urease, lysozyme, catalase and malonic dialdehyde (MDA) were determined in the homogenate of the cheek mucosa. The ratio of catalase and MDA activity was used to calculate the API index, and the ratio of relative urease and lysozyme activity was used to calculate the degree of dysbiosis. Results: In rats received for a long time SOSO, develop in oral mucosa dysbiosis phenomenon, inflammation and decreased activity of the antioxidant system. Lysozyme-forte all restored, surpassing in these indicators Quertulin. Conclusion: Lysozyme-forte has mucosoprotective effect when consumed super-oxidized oil.
Key words: super-oxidized oil, the mucous membrane of the mouth, dysbiosis, inflammation, Lysozyme, antioxidant protective.