DEVELOPMENT AND EVALUATION OF ENTERIC COATED OMEPRAZOLE PELLETS 22.5% W/W

The objective of the present study is to formulate and evaluate enteric coated delayed release pellets of Omeprazole. The formulations of Omeprazole delayed release pellets of were developed by enteric film coating process varying the compositions of drug loading, barrier coating and enteric coating. HPMC E5 was used as enteric polymer. The process variables were standardized and the different batches prepared were evaluated for assay/drug content, water content, acid resistance and dissolution rate. The drug dissolution profiles of Omeprazole delayed release formulations developed were compared with that of innovators product. Based on the results formulation containing enteric coating polymer and plasticizers has been selected as the best formulation developed for Omeprazole delayed release pellets.

Keywords: Enteric coating, Delayed release, Omeprazole, Pellets