Published July 2, 2018 | Version v1
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Antibodies to FimH in Anti-neutrophil cytoplasmic antibody - associated vasculitis

Authors/Creators

  • 1. Institute of Pathology, Medical University Vienna, Austria
  • 2. Department of Medicine III, Division Nephrology and Dialysis, Medical University Vienna, Austria
  • 3. Department of Nephrology, East and North Hertfordshire NHS Trust, UK
  • 4. Department of Microbiology, East and North Hertfordshire NHS Trust, UK
  • 5. Department of Medicine I, Division Infectious diseases and Tropical medicine, Medical University Vienna, Austria
  • 6. Department of Clinical Microbiology, Medical University Vienna, Austria
  • 7. National Food Institute, Technical University of Denmark, DK
  • 8. Department of Medicine, Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA, USA
  • 9. Department of Laboratory Medicine, Medical University Vienna, Austria
  • 10. IT systems and communication, Medical University Vienna, Austria

Description

Peptide microarray containing 4216 unique peptides from 88 different microorganisms represented by validated B-cell epitopes selected from the Immune Epitope Database (http://www.iedb.org). A total of 1509 bacterial, 2311 viral, 12 fungal and 384 protozoal epitopes were printed on the arrays. This array was probed with serum from 8 patients with ANCA-associated vasculitis collected at presentation with the disease as well as in remission and analysed for binding by IgM and IgG.

Notes

Further funding: - ERA-EDTA long-term fellowship (111-2012), - NIHR (IRAS project ID 106330).

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Additional details

Funding

European Commission
RELENT - RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities 668036
European Commission
INTRICATE - Infectious triggers of chronic autoimmunity 261382