Study of motor reflexes formation in rat pups exposed by zeta-cypermethrin in pre-and postnatal periods

Rashkivska Inna, Kornuta Natalia. Study of motor reflexes formation in rat pups exposed by zeta-cypermethrin in pre-and postnatal periods. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;1(51):121-127. ISSN 1818-9385

DOI http://dx.doi.org/10.5281/zenodo.1239802

http://aptm.org.ua

UDК 632.95: 615.91: 612.334: 616: 616.8-009.88

STUDY OF MOTOR REFLEXES FORMATION IN RAT PUPS EXPOSED BY ZETA-CYPERMETHRIN IN PRE- AND POSTNATAL PERIODS

Inna Rashkivska, Natalia Kornuta

L. I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine

Wistar Hannover female rats were exposed with zeta-cypermethrin in doses of 5; 12.5; 35 and 70 mg/kg bw from the 6th day of gestation to the 21st day of lactation. Study of motor reflexes formation during the early postnatal period were investigated. Following physiological tests were performed: "righting reflex", "negative geotaxis", "rotarod", "front-limb strength". The obtained data indicate that the effect of zeta-cypermethrin in the pre- and postnatal period is characterized by dose dependence and sexual sensitivity. Male pups were more sensitive to zeta-cypermethrin at a dose of 70 mg/kg bw.

Key words: synthetic pyrethroids, zeta-сypermethrin, motor reflexes, postnatal period.