Journal article Open Access

Orthologs, Paralogs, and Evolutionary Genomics 1

Koonin, Eugene V.

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A clear distinction between orthologs and paralogs is critical for the construction of a robust evolutionary classification of genes and reliable functional annotation of newly sequenced genomes. Genome comparisons show that orthologous relationships with genes from taxonomically distant species can be established for the majority of the genes from each sequenced genome. This review examines in depth the definitions and subtypes of orthologs and paralogs, outlines the principal methodological approaches employed for identification of orthology and paralogy, and considers evolutionary and functional implications of these concepts.

Files (775.9 kB)
Name Size
article.pdf
md5:19b1a6d75c5f170af2f97c59478348bc
775.9 kB Download
221
253
views
downloads
Views 221
Downloads 253
Data volume 196.3 MB
Unique views 209
Unique downloads 237

Share

Cite as