Journal article Open Access

Caffeine analogs: biomedical impact

Daly, J. W.

.Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes. Such xanthines and other caffeine-inspired heterocycles now provide important research tools and potential therapeutic agents for intervention in Alzheimer's disease, asthma, cancer, diabetes, and Parkinson's disease. Such compounds also have activity as analgesics, antiinflammatories, antitussives, behavioral stimulants, diuretics/natriuretics, and lipolytics. Adverse effects can include anxiety, hypertension, certain drug interactions, and withdrawal symptoms.

Files (350.1 kB)
Name Size
article.pdf
md5:c08f97190f5f49e2970965f2e347cda5
350.1 kB Download
83
56
views
downloads
Views 83
Downloads 56
Data volume 19.6 MB
Unique views 81
Unique downloads 51

Share

Cite as