Journal article Open Access

A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum

You, Jingtao; Wootton, John C.; Wellems, Thomas E.; Ferdig, Michael T.; Huang, Yaming; Huynh, Chuong Q.; Su, Xin-Zhuan; Liu, Anna

Genetic investigations of malaria require a genome-wide, high-resolution linkage map of Plasmodium falciparum. A genetic cross was used to construct such a map from 901 markers that fall into 14 inferred linkage groups corresponding to the 14 nuclear chromosomes. Meiotic crossover activity in the genome proved high (17 kilobases per centimorgan) and notably uniform over chromosome length. Gene conversion events and spontaneous microsatellite length changes were evident in the inheritance data. The markers, map, and recombination parameters are facilitating genome sequence assembly, localization of determinants for such traits as virulence and drug resistance, and genetic studies of parasite field populations.

Files (184.7 kB)
Name Size
article.pdf
md5:c564da79cded46ed20b1b345a0d0dba9
184.7 kB Download
169
133
views
downloads
Views 169
Downloads 133
Data volume 24.6 MB
Unique views 166
Unique downloads 127

Share

Cite as