Journal article Open Access

Kew, O. et al. Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296, 356-359

Morris-Glasgow, Victoria; Landaverde, Mauricio; Shaw, Jing; Sutter, Roland; Tambini, Gina; Venczel, Linda; Pedreira, Cristina; Laender, Fernando; Shimizu, Hiroyuki; Yoneyama, Tetsuo; Miyamura, Tatsuo; van Der Avoort, Harrie; Steven Oberste, M.; Kilpatrick, David; Pallansch, Mark; de Quadros, Ciro; Burns, Cara; Garib, Zacarías; André, Jean; Blackman, Elizabeth; Jason Freeman, C.; Jorba, Jaume; Kew, Olen; Cochi, Stephen

An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.

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