Published May 1, 2002
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Kew, O. et al. Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296, 356-359
Authors/Creators
- Morris-Glasgow, Victoria
- Landaverde, Mauricio
- Shaw, Jing
- Sutter, Roland
- Tambini, Gina
- Venczel, Linda
- Pedreira, Cristina
- Laender, Fernando
- Shimizu, Hiroyuki
- Yoneyama, Tetsuo
- Miyamura, Tatsuo
- van Der Avoort, Harrie
- Steven Oberste, M.
- Kilpatrick, David
- Pallansch, Mark
- de Quadros, Ciro
- Burns, Cara
- Garib, Zacarías
- André, Jean
- Blackman, Elizabeth
- Jason Freeman, C.
- Jorba, Jaume
- Kew, Olen
- Cochi, Stephen
Description
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.
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