Antagonism of Ethanol Intoxication in Rats by Inhibitors of Phenylethanolamine N-Methyltransferase

The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N‐methyltransferase (PNMT), LY 134046 and LY78335, proved to be potent and long‐lasting antagonists of ethanol intoxication in rats. Acute antagonism of pentobarbital‐induced intoxication was observed with LY 134046. The present results are compatible with role for central epinephrine synthesis in ethanol and pentobarbital‐induced sedation and intoxication in rats.