Genomic structure of theEPHA1receptor tyrosinekinase gene

Some receptor tyrosine kinase genes are mutated in inherited and somatically acquired human cancers. To permit mutational analysis, the complete genomic structure of the humanEPHA1gene on chromosome 7q34 was determined and oligonucleotide pairs were designed to amplify coding regions. The gene contains 18 exons, two more than the related tyrosine kinase,EPHB2. Presumed sequencing errors in the published cDNA sequence ofEPHA1were identified in exons 10 and 11. Availability of this information will facilitate mutational analysis ofEPHA1.