Mybl2(Bmyb) Maps to Mouse Chromosome 2 and Human Chromosome 20q13.1

Mybl2encodes a transcription factor that is thought to play an important role in cell cycle progression. Here we report the chromosomal localization ofMybl2in mouse and human. Using mouseMybl2cDNA clones as probes, we assignedMybl2in an interspecific backcross panel to distal Chromosome 2. Using human cDNA probes in combination with FISH analysis, we localizedMYBL2to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders. Both chromosomal regions are highly homologous, and the map positions, therefore, confirm each other. However, our findings are in contrast to a previous report by Barlettaet al.(Cancer Res.51: 3821–3824, 1991) that placed theMYBL2gene on human chromosome Xq13.