Locations of Human and Mouse Genes Encoding theRFX1andRFX2Transcription Factor Proteins

RFX transcription factors constitute a highly conserved family of site-specific DNA binding proteins involved in the expression of a variety of cellular and viral genes, including major histocompatibility complex class II genes and genes in human hepatitis B virus. Five members of the RFX gene family have been isolated from human and mouse, and all share a highly characteristic DNA binding domain that is distinct from other known DNA binding motifs. The humanRFX1andRFX2genes have been assigned byin situhybridization to chromosome 19p13.1 and 19p13.3, respectively. In this paper, we present data that localizeRFX1andRFX2precisely within the detailed physical map of human chromosome 19 and genetic data that assignRfx1andRfx2to homologous regions of mouse chromosomes 8 and 17, respectively. These data define the established relationships between these homologous mouse and human regions in further detail and provide new tools for linking cloned genes to phenotypes in both species.